![Application Note 041](/media/fqmgugmp/application-notes-hero3.jpg?anchor=center&mode=crop&width=1900&height=600&rnd=132398055850870000)
Analysis of the residual solvent dimethyl sulfoxide in a drug precursor
Application Note 041
Many samples require intensive sample preparation before they can be analysed by GC or GC–MS methods. Conventionally, this is carried out by a single or multi-step solvent extraction, but this can be a complex and difficult procedure for some materials – including many pharmaceuticals.
Critical aspects include selecting a solvent that is neither used in the drug manufacture nor likely to co-elute with the compounds of interest, but will completely dissolve the drug itself. Dissolution also limits the sensitivity of GC(MS) methods.
This application note describes the development of a method to analyse residual dimethyl sulfoxide in a sample of a drug precursor using direct thermal desorption.