Targeting tumour-associated aldo-keto reductase activity with exogenous volatile organic compound (EVOC®) probes using high-capacity sorptive extraction (HiSorb™) and GC–MS to detect lung cancer
Presented at Pittcon 2023
Reliable, accessible early detection of lung cancer could dramatically improve patient treatment and survival. Analysis of exogenous volatile organic compounds (EVOCs) – also known as ‘EVOC Probes’ – in breath has shown potential for rapid, non-invasive disease diagnosis for earlier detection to improve patient outcomes.
The poster demonstrates how HiSorb, a high-capacity sorptive extraction technique, can be used for headspace sampling of EVOC Probes. It shows the technique used to test AKR substrates (aldehydes) as potential EVOC Probes for lung cancer in pre-clinical cell culture media, and how HiSorb has sensitivity to target aldehyde and alcohol EVOCs in small amounts of complex culture media samples.